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Set in Pasadena, California, the show is centered on five characters: two roommate geniuses who work at the California Institute of Technology, experimental physicist Leonard Hofstadter and theoretical physicist Sheldon Cooper; their neighbor across the hall Penny, a blonde waitress and aspiring actress; and Leonard and Sheldon's equally geeky and socially awkward co-workers and friends Howard Wolowitz, an aerospace engineer and a non-PhD from JPL, and Rajesh Koothrappali, an astrophysicist also working at Caltech. The geekiness and intellect of the four guys is contrasted for comic effect with Penny's social skills and common sense. Three other supporting characters have also been promoted to main cast status for a few episodes: Leslie Winkle, a Caltech colleague and ex-lover of both Leonard and Howard; Bernadette Rostenkowski, a microbiology graduate who has worked with Penny part-time as a waitress, dated and recently become engaged to Howard, and earned her PhD; and Amy Farrah Fowler, a neurobiologist who was hooked up with Sheldon via an online dating service (courtesy of Howard and Raj, who were later horrified when Amy turned out to be essentially a female version of Sheldon).
Dr. Leonard Leakey Hofstadter (Johnny Galecki) is an experimental physicist with an IQ of 173 who received his Ph.D. when he was 24 years old. He shares an apartment with colleague and friend Sheldon Cooper. The writers have toyed with a romance between him and neighbor Penny since the pilot, with their unresolved sexual tension being a major force for drama. Leonard dated Penny for most of Season 3, and while they have since broken up, some sexual tension is still apparent. Aside from Penny, Leonard has had romantic relationships with co-worker Dr. Leslie Winkle, physician Dr. Stephanie Barnett, an unnamed French literature PhD, and North Korean spy Joyce Kim. Following his breakup with Penny, Leonard began a relationship with Raj's sister Priya, and it is implied they had a previous brief sexual encounter prior to the start of the series on an occasion when Priya visited Raj. Leonard's family includes two other accomplished scientists: his mother, Dr. Beverly Hofstadter, and his sister, while his brother is a Harvard law professor. Leonard wears glasses and is lactose intolerant.
Dr. Sheldon Lee Cooper (Jim Parsons) is a theoretical physicist, possessing a Bachelors in Science, Masters in Science, Masters in Astronomy, a PhD, an ScD, and an IQ of 187. Originally from East Texas, he was a child prodigy, starting college at the age of 11, and receiving his PhD at age 16. He is calculating, cynical, and asexual. Sheldon exhibits a strict adherence to routine to the point of exhibitingobsessive–compulsive disorder, such as his compulsive need to knock nine times on a door, saying the name of the person(s) he is looking for after each of three knocks (if the door is opened prematurely, he still completes the routine). He has shown a lack of understanding of irony and sarcasm and a complete lack of humility. Sheldon appears to be unique among his family members: His mother, Mary, is a devoutChristian, and his twin sister, Missy, is certainly no scientist. Sheldon is consistently the geekiest character in the show as well as the most overly sensitive and obsessive; sometimes psychotically so, such as when he tried to steal a Lord of the Rings production ring from Leonard and the others. Whenever he tells a joke, or plays a prank, he typically punctuates it with the word "Bazinga!".
Penny (family name as yet unrevealed) (Kaley Cuoco), is Leonard and Sheldon's neighbor across the hallway. Originally from Omaha, Nebraska, she is a waitress at the local Cheesecake Factory and also an aspiring actress. Penny is very outgoing, kind, and assertive, her personality contrasting with those of the guys. She has dated several men during the course of the series, including Kurt, Stuart (from the comic book store), and Zack. Penny and Leonard have had a complicated relationship. Leonard pursued Penny during season 1; they dated briefly at the start of season 2 which led to some awkwardness; they began dating again for most of season 3 but she broke up with him after he told Penny he loved her and she was not ready to reciprocate; however, she has regretted this decision at times. She has been influenced somewhat by the guys, including an obsession with on-line gaming, making references to Star Trek, and realizing that she could no longer date stupid guys. For the most part she cannot stand Sheldon's nerdy, eccentric personality, but at times they have shown to be good friends.
Howard Joel Wolowitz (Simon Helberg) is an engineer at Caltech's Department of Applied Physics who often hangs out at Leonard and Sheldon's apartment. Unlike Sheldon, Leonard, and Raj, Howard lacks a doctorate. He defends this by pointing out that he has a master's degree in Engineering from MIT and that the apparatus he designs are launched into space, unlike the purely abstract work of his friends. Howard lives with his overbearing mother who treats him like a child. While he sometimes expresses irritation at this treatment, for the most part he appears to prefer it. Howard, in turn, dotes on his mother and participates in many of her daily routines. His father left them when he was 11, and, to date, he has never learned why. Howard fancies himself a ladies' man and provides outrageous pick-up lines whenever a female is present, which often comes off as creepy. He is Jewish, although he does not follow most practices of the religion. Howard dated Bernadette Rostenkowski briefly in season 3; they resumed their relationship in season 4, which culminated in their engagement.
Dr. Rajesh Ramayan"Raj" Koothrappali (Kunal Nayyar) is Howard Wolowitz's best friend, and yet another genius of the group; his name is usually shortened to "Raj". He is originally from New Delhi, India, and he works in the Physics department at Caltech, where his area of expertise is particle astrophysics. As with his friends, he is mutually involved with and obsessed with sci-fi and comic books in general and is usually the one to propose various real-life questions about random sci-fi problems, such as the functions of the tails of the Na'vi in Avatar. Raj is extremely shy around women (except for his relatives); he is unable to speak to them unless he drinks alcohol. When Penny is around, Raj usually whispers what he wants to say to Howard or Leonard, who then repeats or responds to what Raj says out loud. Despite his pathology, Raj has often ended up in bed with women, leaving the other guys perplexed. Raj communicates with his parents, Dr. and Mrs. Koothrappali, in India via webcam.
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Episode 24 The Roommate Transmogrification
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